MessageLabs - connection timing out

We are having issues sending emails to customers that are using Message Labs. 

[{LED=451 4.4.395 Target host responded with error. -> 421 4.4.1 Connection timed out };{FQDN=cluster1a.us.messagelabs.com};{IP=216.82.251.230};{LRT=12/11/2017 1:16:48 PM}]

We are sending emails from 198.49.0.3.  We are not marked as blacklisted on any websites too.

Can somebody help with this please? Thank you!